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This site is dedicated to scientific community working on ALS. Our aim is to optimize researchers time and efforts by providing updated, well organized information on novel findings, available resources and research support.
AriSLA - The Foundation for research on ALS - has been set up to make ALS research investments more effective and efficient, to speed up the clinical research impact e and to provide patients with better care, improved conditions and life expectancy. Its aim is to boost Italian excellencies in basic, clinical and technological research. The Foundation founders are Fondazione Cariplo, Fondazione Telethon, Fondazione Vialli and Mauro and AISLA.

 

 

Another goal achieved by a pilot project funded by AriSLA (LoCaLS, Call 2013) that aims to expand knowledge on ALS molecular mechanisms

Dr. Bertoli, Principal Investigator of the Arisla "Locals" project, published on "Scientific reports" the results of his work, important for future studies on the role of Calcium in amyotrophic lateral sclerosis (ALS).

 

 

Ion Calcium (Ca2+) regulates vital information for cell life. In fact, small variations in its concentration - limited in time and space - guides a multitude of biological processes. Ca2+ plays a particularly important role in neurons, and alterations in its metabolism have been implicated in neuronal aging and in several neurodegenerative diseases, including ALS.

In recent years, by using genetic engineering researchers developed several proteins that can act as molecular ion indicators, that allow rapid and accurate measurements of Ca2+ concentration within cells.

In the article "Generation and validation of new adeno-associated viral vectors for the analysis of Ca2+ homeostasis in motor neurons", recently published by Dr. Bertoli, researcher of the University of Padua, Department of Biomedical Sciences, and funded by AriSLA with the LoCaLS / 2013 project, Ca2+ indicators have been genetically modified to be specifically expressed in motor neurons, i.e. cells predominantly affected during ALS.

By using vectors based on attenuated viruses these molecular probes can be addressed with great efficiency to different motor neuron regions and can allow reliable measurements of Ca2+ concentration fluctuations. The work has shown that these probes can be also used in disease models and therefore they can be valuable tools for studying Ca2+ signal alterations in cells and animal models of ALS in order to expand the spectrum of our knowledge on the molecular mechanisms of the pathology.

Download the full article

 

 




     
     
     
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